PERSEUS is an EU-funded groundbreaking research project, devoted to the pursuit of a novel nanotechnology-based cancer therapy for deep-seated, clinically unmanageable, drug-resistant, and metastatic tumours.
At present, practical use of nanotechnology in clinical cancer care is still in its infancy – its full potential yet to be realised. PERSEUS aims to bridge this gap thanks to a novel therapy based on specially engineered nano-systems, made of multifunctional 2D layered nanocrystals. When activated by X rays, the nanosystems provide an effective multimodal therapy, with minimal or no adverse effects. This novel paradigm uses X-rays from common computed tomography (CT) scanners not to kill cancer cells directly, but to trigger and to image the nanosystems, which in turn locally give rise to non-mutagenic oncolytic mechanisms.